NFL picks, predictions against the spread Week 5: 49ers run past Cowboys; Jaguars upset Bills; Packers, Jets win on road

[Vinnie Iyer]

In Sporting News' NFL picks against the spread for Week 5, the 49ers handle the Cowboys again while Josh Allen and the Jaguars come up with another upset over the Bills in London. Also, the Saints, Bengals and Jets rebound to win tough road games.