NFL odds, lines, point spreads: Updated Week 1 betting information for picking every game

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Jovan Alford

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The opening week of the 2022 NFL regular season gets underway on Thursday night -- what better time to check out the latest Week 1 NFL odds? Get all the betting information you need, including every Week 1 spread, moneyline, and over/under, plus advice for this week's best bets.
 
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